Article
Potential contributions of viral envelope and host genetic factors in a human immunodeficiency virus type 1-infected long-term survivor.
Journal of virology - 1 Nov 1998
Grovit-Ferbas K, Ferbas J, Gudeman V, Sadeghi S, Goetz M B, Giorgi J V, Chen I S, O'Brien W A
Abstract excerpt
The lack of clinical progression in some individuals despite prolonged human immunodeficiency virus type 1 (HIV-1) infection may result from infection with less-pathogenic viral strains. To address this question, we examined the HIV-1 envelope protein from a donor with a low viral burden, stable CD4(+) T-lymphocyte counts, and little evidence of CD8(+) T-cell expansion, activation, or immune activity. To avoid...
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