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Unravelling the structural impact of progesterone receptor mutations in myoma and progesterone intolerance through computational modeling.

Computers in biology and medicine - 1 Feb 2026

Saritha F, Aswath Kumar R, Dileep K V

Abstract excerpt

Progesterone (P4) is a steroid hormone involved in the regulation of female reproductive functions. The endogenous progesterone receptor (PR), a member of the nuclear receptor family of ligand-dependent transcription regulators responsible for P4 action in the body through the 'ligand binding domain' (LBD). PR isoforms, PR-A and PR-B, are encoded by a single gene, PGR and variations in this gene can disrupt...

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PGR gene
Leiomyoma
Molecular Docking Simulation
Mutation
Progesterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Progesterone

Uterine Neoplasms

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Identifiers

PMID: 41544537
DOI: 10.1016/j.compbiomed.2026.111476

Genes

PGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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