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Gait variability as a marker of white matter integrity in individuals with Down syndrome

27 Jun 2025

Abstract excerpt

INTRODUCTION: Individuals with Down syndrome (DS) face a significant risk of neurodegeneration, and gait variability may serve as a clinical biomarker of neurological health. This longitudinal parent substudy aimed to explore relationships between gait, white matter (WM) integrity, and cognitive function in DS. METHODS: The associations were investigated between magnetic resonance imaging diffusion tensor imaging...

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PMID: 40579790
DOI: 10.1002/alz.70407

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