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Article

Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.

Carcinogenesis - 1 Mar 2009

Asaka Shin-ichi, Arai Yoshiko, Nishimura Yoji, Yamaguchi Kensei, Ishikubo Tsutomu, Yatsuoka Toshimasa, Tanaka Yoichi, Akagi Kiwamu

Abstract excerpt

The classification of colorectal cancer (CRC) by microsatellite instability (MSI) status is important for effective clinical management. In fact, microsatellite instability-high (MSI-H) cancer has distinctive clinicopathological and molecular features. However, microsatellite instability-low (MSI-L) cancer is not clearly defined. The objective of this study was to further clarify the characteristics of MSI-L CRC....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to MutL Protein Homolog 1

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 19147861
DOI: 10.1093/carcin/bgp017

Genes

KRAS
APC
BRAF
MGMT
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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