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Article

Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.

The Journal of biological chemistry - 7 Mar 1997

Walker D C, Christodoulou J, Craig H J, Simard L R, Ploder L, Howell P L, McInnes R R

Abstract excerpt

To determine the molecular and biochemical basis of intragenic complementation observed at the human argininosuccinate lyase (ASL) locus, we identified the ASL alleles in ASL-deficient cell strains with two unique complementation phenotypes: (i) frequent complementers, strains that participated in the majority of complementation events, and (ii) high activity complementers, strains in which complementation was...

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Source

Identifiers

PMID: 9045711
DOI: 10.1074/jbc.272.10.6777

Genes

ASL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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