Article
Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.
The Journal of biological chemistry - 7 Mar 1997
Walker D C, Christodoulou J, Craig H J, Simard L R, Ploder L, Howell P L, McInnes R R
Abstract excerpt
To determine the molecular and biochemical basis of intragenic complementation observed at the human argininosuccinate lyase (ASL) locus, we identified the ASL alleles in ASL-deficient cell strains with two unique complementation phenotypes: (i) frequent complementers, strains that participated i...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Argininosuccinate Lyase
- Argininosuccinic Aciduria
- COS Cells
- Genetic Complementation Test
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Restriction Mapping
- Sequence Alignment
- Sequence Homology, Amino Acid
- Structure-Activity Relationship