Article
Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R.
Biochemistry - 25 Dec 2001
Sampaleanu L M, Vallée F, Thompson G D, Howell P L
Abstract excerpt
Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction involved in the biosynthesis of arginine in all species and in the production of urea in ureotelic species. In humans, mutations in the enzyme result in the autosomal recessive disorder argininosuccinic aciduria. Intragenic complementation has been demonstrated to occur at the ASL locus, with...
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