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Article

Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis.

The Biochemical journal - 1 Dec 2004

Sampaleanu Liliana M, Codding Penelope W, Lobsanov Yuri D, Tsai May, Smith G David, Horvatin Cathy, Howell P Lynne

Abstract excerpt

Delta crystallin, a taxon-specific crystallin present in avian eye lenses, is homologous to the urea cycle enzyme ASL (argininosuccinate lyase). Although there are two delta crystallin isoforms in duck lenses, ddeltac1 (duck delta1 crystallin) and ddeltac2 (duck delta2 crystallin), only ddeltac2 is catalytically active. Previous structural studies have suggested that residues Ser283 and His162 in the...

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Identifiers

PMID: 15320872
DOI: 10.1042/BJ20040656
PMCID: PMC1134128

Genes

ASL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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