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Article

Human argininosuccinate lyase: a structural basis for intragenic complementation.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 1997

Turner M A, Simpson A, McInnes R R, Howell P L

Abstract excerpt

Intragenic complementation has been observed at the argininosuccinate lyase (ASL) locus. Intragenic complementation is a phenomenon that occurs when a multimeric protein is formed from subunits produced by different mutant alleles of a gene. The resulting hybrid protein exhibits enzymatic activity that is greater than that found in the oligomeric proteins produced by each mutant allele alone. The mutations...

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Source

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Identifiers

PMID: 9256435
DOI: 10.1073/pnas.94.17.9063
PMCID: PMC23030

Genes

ASL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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