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Article

Phosphatidylcholine and N-methylated phospholipids are nonessential in Saccharomyces cerevisiae.

The Journal of biological chemistry - 1 Oct 2004

Choi Jae-Yeon, Martin Wesley E, Murphy Robert C, Voelker Dennis R

Abstract excerpt

Phosphatidylcholine (PtdCho) is the most abundant phospholipid in numerous eukaryotes and is generally thought to be essential for membrane structure and cellular function. We designed a specific test of this idea by using genetic and biochemical manipulation of yeast. Yeast mutants (pem1 pem2Delta) lacking the phosphatidylethanolamine (PtdEtn) methyltransferase enzymes require choline for growth and cannot make...

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Identifiers

PMID: 15269223
DOI: 10.1074/jbc.M405074200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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