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Article

Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.

Molecules (Basel, Switzerland) - 5 Nov 2012

St Onge Robert, Schlecht Ulrich, Scharfe Curt, Evangelista Marie

Abstract excerpt

The many virtues that made the yeast Saccharomyces cerevisiae a dominant model organism for genetics and molecular biology, are now establishing its role in chemical genetics. Its experimental tractability (i.e., rapid doubling time, simple culture conditions) and the availability of powerful tools for drug-target identification, make yeast an ideal organism for high-throughput phenotypic screening. It may be...

Topics

Animals
Antimetabolites, Antineoplastic
Drug Screening Assays, Antitumor
Glycolysis
Humans
Leucovorin
Methotrexate
Molecular Targeted Therapy
Mutagenesis
Neoplasms
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

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Identifiers

PMID: 23128089
DOI: 10.3390/molecules171113098
PMCID: PMC3539408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23128089-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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