Article
Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase.
The Journal of biological chemistry - 30 Oct 1998
Hayashi K, Saga H, Chimori Y, Kimura K, Yamanaka Y, Sobue K
Abstract excerpt
Under conventional culture conditions, smooth muscle cells display their phenotypic modulation from a differentiated to a dedifferentiated state. Here, we established a primary culture system of smooth muscle cells maintaining a differentiated phenotype, as characterized by expression of smooth m...
Topics
- Animals
- Cells, Cultured
- Chick Embryo
- Chloramphenicol O-Acetyltransferase
- Enzyme Inhibitors
- Extracellular Matrix Proteins
- Muscle, Smooth
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphoinositide-3 Kinase Inhibitors
- Signal Transduction
- Somatomedins
- Transcription, Genetic