Article
Changes in proteomic features induced by insulin on vascular smooth muscle cells from spontaneous hypertensive rats in vitro.
Cell biochemistry and biophysics - 1 Nov 2010
Wang Yan, Zhang Bo, Bai Yun, Zeng Chunyu, Wang Xukai
Abstract excerpt
Hyperinsulinemia is a risk factor in atherosclerosis formation that it stimulated vascular smooth muscle cells (VSMCs) proliferation and migration. To understand the underlying molecular mechanism involved in the processes of cellular response to insulin, VSMCs from Wistar-Kyoto rat (WKY) and spontaneous hypertensive rat (SHR) were isolated and cultured, and its proteome was comparatively analyzed with normal...
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