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Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skin

23 Nov 2020

Abstract excerpt

INTRODUCTION: Hyaluronic acid (hyaluronan; HA) is an essential component of the extracellular matrix (ECM) of the skin. The HA-degrading enzyme hyaluronidase (HYAL) is critically involved in the HA-metabolism. Yet, only little information is available regarding the skin's HA-HYAL interactions on the molecular and cellular levels. OBJECTIVE: To analyze the dose- and time-dependent molecular and cellular effects of...

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PMID: 33228813
DOI: 10.1186/s40001-020-00460-z

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