Article
APOE haplotypes influence bone mineral density in Caucasian males but not females.
Calcified tissue international - 1 Oct 2004
Long Ji-Rong, Liu Peng-Yuan, Liu Yong-Jun, Lu Yan, Shen Hui, Zhao Lan-Juan, Xiong Dong-Hai, Deng Hong-Wen
Abstract excerpt
Low bone mineral density (BMD) is one of the most important risk factors for osteoporosis. Apolipoprotein E (APOE) has been considered as a candidate gene for osteoporosis because of its influence on osteoblast uptake of lipoprotein-borne vitamin K. Using the quantitative transmission disequilibrium test QTDT, we examined linkage and/or association of APOE and BMD at the lumbar spine and the total hip in a sample...
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