Article
Estrogen receptor alpha gene relationship with peak bone mass and body mass index in Chinese nuclear families.
Journal of human genetics - 1 Jan 2005
Jian Wei-Xia, Yang Yan-Jun, Long Ji-Rong, Li Yuan-Neng, Deng Fei-Yan, Jiang De-Ke, Deng Hong-Wen
Abstract excerpt
Estrogen receptor alpha (ER-alpha) plays an important role in mediating estrogen signaling. Studies in Caucasian populations have shown that it is involved in endocrine-related diseases such as osteoporosis and obesity. In the present study, we first used a quantitative transmission disequilibrium test (QTDT) to examine the relationship between this gene and both the osteoporosis-related phenotype bone mineral...
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