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Article

Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1.

Journal of cell science - 1 Aug 2004

Choma David P, Pumiglia Kevin, DiPersio C Michael

Abstract excerpt

Epithelial cell migration is a crucial event in wound healing, yet little is known about mechanisms whereby integrins regulate epithelial cell polarization and migration. In the present work, we demonstrate the importance of adhesion through the alpha3beta1 integrin in promoting the stabilization of leading lamellipodia in migrating keratinocytes. We demonstrate that this integrin is found at the leading edge of...

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Source

Identifiers

PMID: 15265981
DOI: 10.1242/jcs.01251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1.PMID 15265981Read ↗

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A novel role for integrin-linked kinase in epithelial sheet morphogenesis.Semantic proximity Read ↗

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Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.Semantic proximity Read ↗

Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion.Semantic proximity Read ↗

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