Article
Relationship between mutations of mitochondrial DNA ND1 gene and type 2 diabetes.
Chinese medical journal - 1 Jul 2004
Yu Pei, Yu De-min, Liu De-min, Wang Kun, Tang Xin-zhi
Abstract excerpt
BACKGROUND: Recent studies have indicated that many mutations in mitochondrial (mt) DNA NDI gene region are related to diabetes mellitus. In this study we explored the relationship between various mtDNA ND1 gene mutations and type 2 diabetes mellitus (DM) among Chinese. METHODS: Using PCR restriction fragment length polymorphism (PCR-RFLP) analysis and gene sequencing, 4 spots of mtDNA (nt3243, nt3316, nt3394,...
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