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Article

Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice.

The Journal of experimental medicine - 19 Jul 2004

Quandt Jacqueline A, Baig Mirza, Yao Karen, Kawamura Kazuyuki, Huh Jaebong, Ludwin Samuel K, Bian Hong-Jin, Bryant Mark, Quigley Laura, Nagy Zoltan A, McFarland Henry F, Muraro Paolo A, Martin Roland, Ito Kouichi

Abstract excerpt

Amino acid residues 111-129 represent an immunodominant epitope of myelin basic protein (MBP) in humans with human leukocyte antigen (HLA)-DRB1*0401 allele(s). The MBP 111-129-specific T cell clone MS2-3C8 was repeatedly isolated from a patient with multiple sclerosis (MS), suggesting an involvement of MS2-3C8 T cells in the pathogenesis. To address the pathogenic potential of the MS2-3C8 T cell clone, we...

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Share to Cell Separation
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

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Source

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Identifiers

PMID: 15263029
DOI: 10.1084/jem.20030994
PMCID: PMC2212014

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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