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Article

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins.

The Journal of biological chemistry - 13 Oct 2000

Qiu W, Zhuang S, von Lintig F C, Boss G R, Pilz R B

Abstract excerpt

Cyclic AMP can either activate or inhibit the mitogen-activated protein kinase (MAPK) pathway in different cell types; MAPK activation has been observed in B-Raf-expressing cells and has been attributed to Rap1 activation with subsequent B-Raf activation, whereas MAPK inhibition has been observed in cells lacking B-Raf and has been attributed to cAMP-dependent protein kinase (protein kinase A)-mediated...

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Source

Identifiers

PMID: 10931830
DOI: 10.1074/jbc.M003327200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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