Back to search

Article

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation

2025-09-08

Abstract excerpt

Unfolded protein response (UPR) promotes protein homeostasis under endoplasmic reticulum stress. UPR signaling has numerous functions in metabolism, cancer, immunology, and neurodegenerative diseases. Recent studies also showed that UPR signaling has important roles in hematopoietic stem and progenitor cell biology. However, whether UPR signaling regulates hematopoietic lineage fate decision remains elusive. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5ba78def-a522-51cf-8171-ac459cca4ea8
DOI
10.1101/2025.09.07.674755
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutationDOI 10.1101/2025.09.07.674755
Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemiaSemantic proximity
The special unfolded protein response in plasma cellsSemantic proximity
The Unfolded Protein Response: A Novel Therapeutic Target in Acute LeukemiasSemantic proximity
UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid DevelopmentSemantic proximity
Molecular physiology of plasma cell differentiationSemantic proximity
pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.Semantic proximity
A role for the unfolded protein response in optimizing antibody secretion.Semantic proximity
Molecular Insights into the Oxygen-Sensing Pathway and Erythropoietin Expression Regulation in ErythropoiesisSemantic proximity
Immunoproteasome Genes Are Modulated in CD34+ JAK2V617F Mutated Cells from Primary Myelofibrosis Patients.Semantic proximity
Calreticulin Affects Hematopoietic Stem/Progenitor Cell Fate by Impacting Erythroid and Megakaryocytic DifferentiationSemantic proximity
CD62L expression level determines the cell fate of myeloid progenitorsSemantic proximity
Non‐steady‐state hematopoiesis regulated by the C/<scp>EBP</scp>β transcription factorSemantic proximity
Select a neighboring publication to make it the new centre.