Article
Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism.
Clinical pharmacology and therapeutics - 1 May 1997
Okumura K, Kita T, Chikazawa S, Komada F, Iwakawa S, Tanigawara Y
Abstract excerpt
We studied the genotypes of polymorphic N-acetyltransferase (NAT2) in 145 Japanese subjects by the polymerase chain reaction-restriction fragment length polymorphism method. The rapid-type NAT2*4 was expressed at a higher frequency (68.6%) than the slow-type genes with specific point mutations (NAT2*6A, 19.3%; NAT2*7B, 9.7%; NAT2*5B, 2.4%). The frequency of NAT2* genotypes consisted of 44% of a homozygote of...
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