Article
Studies on N-Acetyltransferase (NAT2) Genotype Relationships in Emiratis: Confirmation of the Existence of Phenotype Variation among Slow Acetylators.
Annals of human genetics - 1 Sept 2017
Al-Ahmad Mohammad M, Amir Naheed, Dhanasekaran Subramanian, John Anne, Abdulrazzaq Yousef M, Ali Bassam R, Bastaki Salim
Abstract excerpt
BACKGROUND AND PURPOSE: Individuals with slow N-acetylation phenotype often experience toxicity from drugs such as isoniazid, sulfonamides, procainamide, and hydralazine, whereas rapid acetylators may not respond to these medications. The highly polymorphic N-acetyltransferase 2 enzyme encoded by the NAT2 gene is one of the N-acetylators in humans with a clear impact on the metabolism of a significant number of...
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