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Article

Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2004

Wilding Craig S, Relton Caroline L, Sutton Matthew J, Jonas Pat A, Lynch Sally-Ann, Tawn E Janet, Burn John

Abstract excerpt

BACKGROUND: A 28-bp repeat polymorphism in the 5'UTR of the thymidylate synthase (TYMS) gene represents a candidate risk factor for neural tube defects (NTDs) due to involvement in folate-dependent homocysteine metabolism. Non-Hispanic, white, U.S. citizens carrying at least one 2x 28-bp repeat allele have recently been shown to be at a four-fold increased risk of spina bifida (SB). We investigated the...

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Identifiers

PMID: 15259039
DOI: 10.1002/bdra.20038

Genes

TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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