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Article

Associations between polymorphisms within the thymidylate synthase gene and spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Nov 2003

Volcik Kelly A, Shaw Gary M, Zhu Huiping, Lammer Edward J, Laurent Cecile, Finnell Richard H

Abstract excerpt

BACKGROUND: Polymorphisms within the thymidylate synthase (TS) gene that influence enzyme activity may affect plasma folate levels and, indirectly, plasma homocysteine concentrations. We investigated whether TS polymorphisms contribute to spina bifida (SB) risk, given that a reduction in the risk...

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PMID: 14745930
DOI: 10.1002/bdra.10029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14745930-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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