Article
Mutations of the interferon sensitivity-determining region (ISDR) correlate with the complexity of hypervariable region (HVR)-1 in the Japanese variant of hepatitis C virus (HCV) type 1b.
Journal of medical virology - 1 Sept 2004
Nakano Isao, Fukuda Yoshihide, Katano Yoshiaki, Toyoda Hidenori, Hayashi Kazuhiko, Kumada Takashi, Nakano Satoshi
Abstract excerpt
Hepatitis C virus (HCV) genotype 1b comprises mainly two subtypes in Japan, each named for its geographic prevalence (Japan-specific, J type; worldwide, W type). Because the newly identified subtypes have not been fully characterized, the present study directed this issue from virological viewpoints such as hypervariable region (HVR)-1 as well as interferon (IFN) sensitivity-determining region (ISDR). Fifty...
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