Article
[Mutations within the interferon sensitivity determining region in Korean patients infected with hepatitis C virus genotype 1b].
The Korean journal of hepatology - 1 Jun 2010
Jin Young-Joo, Park Yoon Kyung, Yun Gui Jun, Lee Han Chu, Jeong Sook-Hyang, Kim Gang Mo, Lim Young-Suk, Chung Young-Hwa, Lee Yung Sang, Suh Dong Jin
Abstract excerpt
BACKGROUND/AIMS: The treatment response to interferon could differ with mutations in the interferon-sensitivity-determining region (ISDR) in patients infected with hepatitis C virus (HCV) genotype-1b (HCV-Ib). We examined the pattern of ISDR mutations and analyzed whether the number of amino acid substitutions influences the treatment response to peginterferon plus ribavirin in chronic hepatitis or cirrhotic...
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