Article
A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1B.
Journal of medical virology - 1 Jan 2007
Murayama Mutsumi, Katano Yoshiaki, Nakano Isao, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Hirooka Yoshiki, Itoh Akihiro, Goto Hidemi
Abstract excerpt
The interferon sensitivity-determining region (ISDR) is useful as a predictive marker of the response to interferon (IFN) therapy for chronic hepatitis patients with a Japan-specific subtype (J-type) of hepatitis C virus (HCV) genotype 1b. This marker is not useful for predicting responsiveness of a worldwide subtype (W-type) of HCV 1b, which could explain the restricted usefulness of this system only to Japan....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.