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Article

Variable var transition rates underlie antigenic variation in malaria.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2004

Horrocks Paul, Pinches Robert, Christodoulou Zóe, Kyes Sue A, Newbold Chris I

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is expressed on the surface of infected erythrocytes where it plays a central role in both infected erythrocytes cytoadhesion and immune evasion. Switches in clonal expression of PfEMP1 result in antigenic variation that facilitates long-term chronic infection of the host. The var gene family encodes PfEMP1 variants, with transcriptional switching...

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Identifiers

PMID: 15256597
DOI: 10.1073/pnas.0402347101
PMCID: PMC503751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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