Article
Presenilin 1 is essential for cardiac morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2004
Nakajima Mitsunari, Moriizumi Eiko, Koseki Haruhiko, Shirasawa Takuji
Abstract excerpt
Presenilin 1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. PS1-deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1-deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using...
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