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Article

Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Uh Kyungjun, Monarch Kaylynn, Reese Emily D, Rodriguez Katherine, Yoon Junchul, Spate Lee D, Samuel Melissa S, Koh Sehwon, Chen Paula R, Jarome Timothy J, Allen Timothy A, Prather Randall S, Lee Kiho

Abstract excerpt

Background: Presenilin 1 (PSEN1) is one of the genes linked to the prevalence of early onset Alzheimer's disease. In mice, inactivation of Psen1 leads to developmental defects, including vertebral malformation and neural development. However, little is known about the role of PSEN1 during the development in other species. Objective: To investigate the role of PSEN1 in vertebral development and the pathogenic...

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Identifiers

PMID: 39177593
DOI: 10.3233/JAD-231297
PMCID: PMC11492100

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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