Article
Skeletal and CNS defects in Presenilin-1-deficient mice.
Cell - 16 May 1997
Shen J, Bronson R T, Chen D F, Xia W, Selkoe D J, Tonegawa S
Abstract excerpt
Presenilin-1 (PS1) is the major gene responsible for early-onset familial Alzheimer's disease (FAD). To understand the normal function of PS1, we have generated a targeted null mutation in the murine homolog of PS1. We report that PS1-/- mice die shortly after natural birth or Caesarean section....
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