Article
Hepatitis C virus mutation affects proteasomal epitope processing.
The Journal of clinical investigation - 1 Jul 2004
Seifert Ulrike, Liermann Heike, Racanelli Vito, Halenius Anne, Wiese Manfred, Wedemeyer Heiner, Ruppert Thomas, Rispeter Kay, Henklein Peter, Sijts Alice, Hengel Hartmut, Kloetzel Peter-M, Rehermann Barbara
Abstract excerpt
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an immunodominant HLA-A2-restricted CD8 cell epitope that is frequently recognized by recovered patients. The mutation, a conservative HCV nonstructural protein 3 (NS3)...
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