Cross talk between retinoic acid signaling and transcription factor GATA-2.

doi:10.1128/MCB.24.15.6824-6836.2004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cross talk between retinoic acid signaling and transcription factor GATA-2.

Molecular and cellular biology - 1 Aug 2004

Tsuzuki Shinobu, Kitajima Kenji, Nakano Toru, Glasow Annegret, Zelent Arthur, Enver Tariq

Abstract excerpt

All-trans-retinoic acid (RA) stimulates differentiation of normal hematopoietic progenitors and acute myeloid leukemia cells. GATA-2 is a transcription factor expressed in early progenitor cells and implicated in the control of the fate of hematopoietic stem cells and progenitor cells. We have investigated the possibility that the GATA and nuclear hormone receptor pathways are functionally linked through direct...

Topics

Amino Acid Motifs
Animals
Blotting, Western
Cell Differentiation
Cell Line
Cell Line, Tumor
DNA
DNA-Binding Proteins
GATA2 Transcription Factor
Genetic Vectors
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Luciferases

Mice

Models, Genetic

Mutation

Plasmids

Precipitin Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 15254248
DOI: 10.1128/MCB.24.15.6824-6836.2004
PMCID: PMC444844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross talk between retinoic acid signaling and transcription factor GATA-2.PMID 15254248Read ↗

PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cellsSemantic proximity Read ↗

Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia.Semantic proximity Read ↗

Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Semantic proximity Read ↗

Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid.Semantic proximity Read ↗

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.Semantic proximity Read ↗

Retinoid X receptor alpha (RXRalpha) helix 12 plays an inhibitory role in the recruitment of the p160 co-activators by unliganded RXRalpha/retinoic acid receptor alpha heterodimers.Semantic proximity Read ↗

DNA methylation-independent loss of RARA gene expression in acute myeloid leukemiaSemantic proximity Read ↗

Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.Semantic proximity Read ↗

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.Semantic proximity Read ↗

Physical Interaction Between Retinoic Acid Receptor and Sp1: Mechanism for Induction of Urokinase by Retinoic AcidSemantic proximity Read ↗

Retinoic acid signal transduction pathways.Semantic proximity Read ↗

Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.