Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.

doi:10.1016/0092-8674(90)90531-i

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Article

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.

Cell - 4 May 1990

Schüle R, Umesono K, Mangelsdorf D J, Bolado J, Pike J W, Evans R M

Abstract excerpt

We present evidence that the vitamin D response element in the human osteocalcin gene confers responsiveness to the vitamin A metabolite, retinoic acid. Retinoic acid receptor (RAR) expressed in E. coli binds to this sequence in vitro. Transfection of RAR expression vectors in cultured cells activates heterologous promoters containing this sequence in vivo. This response element contains a consensus AP-1 site...

Topics

Animals
Base Sequence
Binding Sites
Carrier Proteins
Cell Line
Cholecalciferol
Chromosome Deletion
DNA-Binding Proteins
Genes
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Osteocalcin

Promoter Regions, Genetic

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-fos

Proto-Oncogene Proteins c-jun

Source

Open in PubMed

Identifiers

PMID: 2159384
DOI: 10.1016/0092-8674(90)90531-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2159384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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