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Article

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.

Cell - 4 May 1990

Schüle R, Umesono K, Mangelsdorf D J, Bolado J, Pike J W, Evans R M

Abstract excerpt

We present evidence that the vitamin D response element in the human osteocalcin gene confers responsiveness to the vitamin A metabolite, retinoic acid. Retinoic acid receptor (RAR) expressed in E. coli binds to this sequence in vitro. Transfection of RAR expression vectors in cultured cells activates heterologous promoters containing this sequence in vivo. This response element contains a consensus AP-1 site...

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Identifiers

PMID: 2159384
DOI: 10.1016/0092-8674(90)90531-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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