Article
Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid.
The Journal of biological chemistry - 23 Apr 2004
Hong SunHwa, Choi Hyun Mi, Park Min Jung, Kim Young Hee, Choi Yoon Ha, Kim Hyung Hoi, Choi Young Hyun, Cheong JaeHun
Abstract excerpt
Terminal differentiation of hematopoietic cells follows a precisely orchestrated program of transcriptional regulatory events at the promoters of both lineage-specific and ubiquitous genes. Here we show that the transcription factor ATF2 is associated with the induction of granulocytic differentiation, and the molecular interaction of ATF2 with a tissue-specific coactivator activating signal cointegator-2 (ASC-2)...
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