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Article

TGF-<i>β</i>1/Smads and miR-21 in Renal Fibrosis and Inflammation

1 Jan 2016

Abstract excerpt

Renal fibrosis, irrespective of its etiology, is a final common stage of almost all chronic kidney diseases. Increased apoptosis, epithelial-to-mesenchymal transition, and inflammatory cell infiltration characterize the injured kidney. On the molecular level, transforming growth factor-β1 (TGF-β1)-Smad3 signaling pathway plays a central role in fibrotic kidney disease. Recent findings indicate the prominent role...

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PMID: 27610006
DOI: 10.1155/2016/8319283

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