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Article

PIASy inhibits virus-induced and interferon-stimulated transcription through distinct mechanisms.

The Journal of biological chemistry - 11 Mar 2011

Kubota Toru, Matsuoka Mayumi, Xu Songxiao, Otsuki Noriyuki, Takeda Makoto, Kato Atsushi, Ozato Keiko

Abstract excerpt

The protein inhibitor of activated STAT (PIAS) family proteins regulates innate immune responses by controlling transcription induced by Toll-like receptor, RIG-I-like receptor signaling, and JAK/STAT pathways. Here, we show that PIASy negatively regulates type I interferon (IFN) transcription. V...

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Identifiers

PMID: 21199872
DOI: 10.1074/jbc.M110.195255
PMCID: PMC3048703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21199872-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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