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Article

TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator.

The Journal of biological chemistry - 12 Jul 2013

Meyer Florencia, Ehlers Erica, Steadman Andrew, Waterbury Thomas, Cao Mingxia, Zhang Luwen

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is a human γ-herpesvirus. KSHV replication and transcription activator (RTA) is necessary and sufficient for KSHV reactivation from latency. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns, act through adaptors, and initiate innate and adaptive immune responses against pathogens. Toll/interleukin-1-receptor domain containing adaptor...

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Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to Herpesvirus 8, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Immediate-Early Proteins

Share to Nuclear Pore Complex Proteins

Share to RNA-Binding Proteins

Share to Toll-Like Receptor 3

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Source

Open in PubMed Open full text

Identifiers

PMID: 23723066
DOI: 10.1074/jbc.M113.487421
PMCID: PMC3711309

Genes

TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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