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Article

Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model

1 Sept 2009

Abstract excerpt

The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, B7-H1 and B7-DC, has been suggested to play an important role in tumor evasion from host immunity. Pancreas cancer patients with B7-H1 expression have a poor prognosis. B7-H1 blocking has been shown to inhibit the development of a subcutaneous tumor from a pancreas cancer cell line. In this study, we investigated the...

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PMID: 19724910
DOI: 10.3892/ijo_00000387

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