Article
[Clinical significance of mutant p53 protein expression in lung adenocarcinoma].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Jan 2015
Bian Chun'an, Li Zhongyou, Xu Youtao, Wang Jie, Xu Lin, Shen Hongbing
Abstract excerpt
BACKGROUND: P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of the tumor protein P53 gene (TP53) mutation in lung adenocarcinoma are indefinite. The aim of this study is to explore the clinical significance of the mutant P53 protein...
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