Article
Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27.
Arthritis and rheumatism - 1 Jul 2004
Penttinen Markus A, Heiskanen Kaisa M, Mohapatra Rajashree, DeLay Monica L, Colbert Robert A, Sistonen Lea, Granfors Kaisa
Abstract excerpt
OBJECTIVE: To reveal the cause of the impaired elimination of Salmonella enteritidis in HLA-B27-transfected human monocytic cells and to study whether the B pocket of HLA-B27 contributes to these modulatory effects. METHODS: Stable U937 cell transfectants expressing HLA-A2, B27, or different forms of B27 with amino acid substitutions in the B pocket were prepared. Mock-transfected cells were prepared using the...
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