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Article

Enhanced phosphorylation of STAT-1 is dependent on double-stranded RNA-dependent protein kinase signaling in HLA-B27-expressing U937 monocytic cells.

Arthritis and rheumatism - 1 Mar 2012

Ruuska Marja, Sahlberg Anna S, Colbert Robert A, Granfors Kaisa, Penttinen Markus A

Abstract excerpt

OBJECTIVE: To study the phosphorylation of STAT-1 in HLA-B27-transfected human monocytic cells and the role of the signaling molecules double-stranded RNA-dependent protein kinase (PKR) and p38 in STAT-1 phosphorylation. METHODS: U937 human monocytic cell transfectants stably expressing wild-type HLA-B27 or mutated HLA-B27 heavy chains with amino acid substitutions in the B pocket were prepared. Mock-transfected...

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Identifiers

PMID: 21968657
DOI: 10.1002/art.33391
PMCID: PMC3271176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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