Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

Pharmacology, biochemistry, and behavior - 1 Oct 2011

Kinsey Steven G, Naidu Pattipati S, Cravatt Benjamin F, Dudley David T, Lichtman Aron H

Abstract excerpt

Fatty acid amide hydrolase (FAAH) is the primary degradative enzyme of the endocannabinoid anandamide (N-arachidonoylethanolamine), which activates cannabinoid CB(1) and CB(2) receptors. FAAH disruption reduces nociception in a variety of acute rodent models of inflammatory pain. The present study investigated whether these actions extend to the chronic, collagen-induced arthritis (CIA) model. We investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Arthritis, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbamates

Share to Hyperalgesia

Share to Pain Measurement

Share to Receptor, Cannabinoid, CB1

Share to Receptor, Cannabinoid, CB2

Source

Open in PubMed Open full text

Identifiers

PMID: 21740924
DOI: 10.1016/j.pbb.2011.06.022
PMCID: PMC3164582

Genes

FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.PMID 21740924Read ↗

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.Semantic proximity Read ↗

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia.Semantic proximity Read ↗

Functional disassociation of the central and peripheral fatty acid amide signaling systems.Semantic proximity Read ↗

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.Semantic proximity Read ↗

Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.Semantic proximity Read ↗

Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.Semantic proximity Read ↗

Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task.Semantic proximity Read ↗

Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents.Semantic proximity Read ↗

Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody‐induced arthritis mouse modelSemantic proximity Read ↗

The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis.Semantic proximity Read ↗

Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis.Semantic proximity Read ↗

Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.