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Article

Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique.

Annals of the New York Academy of Sciences - 1 Jun 2004

Lowe J, Sheerin A, Jennert-Burston K, Burton D, Ostler E L, Bird J, Green M H L, Faragher R G A

Abstract excerpt

Werner syndrome (WS) is an inherited genetic disease in which individuals display the premature aging of a selected subset of tissues. The disorder results from the loss of function mutations in the wrn gene. Wrn codes for a member of the RecQ helicase family with a unique nuclease domain. There is significant evidence that the role of wrn is to assist in the repair and reinitiation of DNA replication forks that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15247024
DOI: 10.1196/annals.1297.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique.PMID 15247024Read ↗

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Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.Semantic proximity Read ↗

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Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.Semantic proximity Read ↗

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