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Article

The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.

Cancer chemotherapy and pharmacology - 1 Apr 2009

Innocenti Federico, Mirkov Snezana, Nagasubramanian Ramamoorthy, Ramírez Jacqueline, Liu Wanqing, Bleibel Wasim K, Shukla Sunita J, Hennessy Kathleen, Rosner Gary L, Cook Edwin, Eileen Dolan M, Ratain Mark J

Abstract excerpt

PURPOSE: Werner's syndrome (WS) is a recessive disorder of premature onset of processes associated with aging. Defective DNA repair has been reported after exposure of cells isolated from WS patients to DNA-damaging agents. The germline 4330T>C (Cys1367Arg) variant in the WS gene (WRN) has been associated with protection from age-related diseases, suggesting it has a functional role. We studied whether the...

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Identifiers

PMID: 18677484
DOI: 10.1007/s00280-008-0793-8
PMCID: PMC2731557

Genes

WRN

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