Article
Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status.
Carcinogenesis - 1 Aug 2005
Tan Wen, Miao Xiaoping, Wang Li, Yu Chunyuan, Xiong Ping, Liang Gang, Sun Tong, Zhou Yifeng, Zhang Xuemei, Li Hui, Lin Dongxin
Abstract excerpt
Thymidylate synthase (TS) catalyzes the 5,10-methylene-tetrahydrofolate-mediated conversion of deoxyuridine monophosphate to deoxythymydine monophosphate, a nucleotide required for DNA synthesis and repair. The impaired TS expression has been shown to be related to 28 bp tandem repeats and a G-->C SNP in the 5'-UTR of TS. Folate deficiency has been demonstrated to play a role in gastroesophageal carcinogenesis....
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