Article
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2005
Wang L-D, Guo R-F, Fan Z-M, He X, Gao S-S, Guo H-Q, Matsuo K, Yin L-M, Li J-L
Abstract excerpt
SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis. Common polymorphisms at the MTHFR nucleotides position 677 (C-T) and a 28-bp tandem repeat polymorphism (2R or 3R) in the TS promoter enhancer region (TSER) have been reported to be functional and are supposed to disturb the normal...
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