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Article

A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection

1 Dec 2007

Abstract excerpt

OBJECTIVE: In Old World monkeys, the tripartite motif 5alpha (TRIM5alpha) protein confers resistance to HIV-1 infection following virus entry into host cells. However, the pig-tailed macaque (Macaca nemestrina) is an exception and is susceptible to HIV-1 infection. This study dissects the molecular mechanism of the pig-tailed macaque's susceptibility to HIV-1 infection. METHODS: Genomic sequencing and expression...

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Identifiers

PMID: 18172386
DOI: 10.1097/01.aids.0000304692.09143.1b

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Related research

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Research trail→

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A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infectionPMID 18172386Read ↗

Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection.Semantic proximity Read ↗

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Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.Semantic proximity Read ↗

TRIMCyp expression in Old World primates <i>Macaca nemestrina</i> and <i>Macaca fascicularis</i>Semantic proximity Read ↗

Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates.Semantic proximity Read ↗

The TRIMCyp genotype in four species of macaques in China.Semantic proximity Read ↗

TRIM5α and Species Tropism of HIV/SIVSemantic proximity Read ↗

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