Article
Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia.
Molecular psychiatry - 1 Dec 2004
Park N, Juo S H, Cheng R, Liu J, Loth J E, Lilliston B, Nee J, Grunn A, Kanyas K, Lerer B, Endicott J, Gilliam T C, Baron M
Abstract excerpt
The low-to-moderate resolution of linkage analysis in complex traits has underscored the need to identify disease phenotypes with presumed genetic homogeneity. Bipolar disorder (BP) accompanied by psychosis (psychotic BP) may be one such phenotype. We previously reported a genome-wide screen in a large bipolar pedigree sample. In this follow-up study, we reclassified the disease phenotype based on the presence or...
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