Article
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.
Biological psychiatry - 1 Mar 2014
Bramon Elvira, Pirinen Matti, Strange Amy, Lin Kuang, Freeman Colin, Bellenguez Céline, Su Zhan, Band Gavin, Pearson Richard, Vukcevic Damjan, Langford Cordelia, Deloukas Panos, Hunt Sarah, Gray Emma, Dronov Serge, Potter Simon C, Tashakkori-Ghanbaria Avazeh, Edkins Sarah, Bumpstead Suzannah J, Arranz Maria J, Bakker Steven, Bender Stephan, Bruggeman Richard, Cahn Wiepke, Chandler David, Collier David A, Crespo-Facorro Benedicto, Dazzan Paola, de Haan Lieuwe, Di Forti Marta, Dragović Milan, Giegling Ina, Hall Jeremy, Iyegbe Conrad, Jablensky Assen, Kahn René S, Kalaydjieva Luba, Kravariti Eugenia, Lawrie Stephen, Linszen Don H, Mata Ignacio, McDonald Colm, McIntosh Andrew, Myin-Germeys Inez, Ophoff Roel A, Pariante Carmine M, Paunio Tiina, Picchioni Marco, Ripke Stephan, Rujescu Dan, Sauer Heinrich, Shaikh Madiha, Sussmann Jessika, Suvisaari Jaana, Tosato Sarah, Toulopoulou Timothea, Van Os Jim, Walshe Muriel, Weisbrod Matthias, Whalley Heather, Wiersma Durk, Blackwell Jenefer M, Brown Matthew A, Casas Juan P, Corvin Aiden, Duncanson Audrey, Jankowski Janusz A Z, Markus Hugh S, Mathew Christopher G, Palmer Colin N A, Plomin Robert, Rautanen Anna, Sawcer Stephen J, Trembath Richard C, Wood Nicholas W, Barroso Ines, Peltonen Leena, Lewis Cathryn M, Murray Robin M, Donnelly Peter, Powell John, Spencer Chris C A
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories. METHODS: 1239 cases with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder; 857 of their unaffected relatives, and 2739 healthy controls were genotyped with...
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